The Go Bowling 250 will round out his Xfinity Series schedule this year.
Busch will drive the No. 54 Joe Gibbs Racing Toyota in the race.
In his four Xfinity races this year, Busch has one win at Charlotte Motor Speedway, three top fives and three top 10s.
At Richmond, Busch has six wins, 16 top fives and 19 top 10s in 22 Xfinity starts.
The reigning Cup Series champion is the winning-est Xfinity driver, with 97 wins in 356 career starts.
The Go Bowling 250 will take place on Friday, Sept. 11 at 7 p.m. ET, with TV coverage provided by NBC Sports Network.